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BN42010M-50ul
50ul
￥1486.00
交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF
BN42010M-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF
產(chǎn)品描述
| 英文名稱 | GAP43 |
| 中文名稱 | 神經(jīng)生長相關(guān)蛋白43單克隆抗體 |
| 別 名 | Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 神經(jīng)生物學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 6F11 |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human GAP43 Protein: |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Subunit: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. Post-translational modifications: Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. Similarity: Belongs to the neuromodulin family. Contains 1 IQ domain. SWISS: P17677 Gene ID: 2596 Database links: Entrez Gene: 2596 Human Entrez Gene: 14432 Mouse GenBank: NP_002036 Human Omim: 162060 Human SwissProt: P17677 Human SwissProt: P06837 Mouse Unigene: 134974 Human Unigene: 1222 Mouse Unigene: 10928 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）；神經(jīng)標(biāo)志物 GAP43 （Growth associated protein-43）又稱作neuromodulin，是一個(gè)軸突膜蛋白，是一種神經(jīng)特異性的蛋白質(zhì)，參與神經(jīng)細(xì)胞外生長及突觸發(fā)育形成和神經(jīng)細(xì)胞再生。在神經(jīng)元發(fā)育和再生過程中以高水平表達(dá)。能調(diào)解軸突延伸作用，改變細(xì)胞形態(tài)。作為細(xì)胞內(nèi)信號，可大大增強(qiáng)與G蛋白偶聯(lián)的受體轉(zhuǎn)運(yùn)作用。 神經(jīng)生長相關(guān)蛋白-GAP-43和神經(jīng)細(xì)胞黏附因子(neural cell adhesion molecule,NCAM)與突觸可塑性密切相關(guān).GAP-43是一種神經(jīng)細(xì)胞膜上的特異性磷蛋白,在神經(jīng)發(fā)育和再生過程中呈現(xiàn)高表達(dá),被作為突觸生長的標(biāo)志物,有稱脊髓生長相關(guān)蛋白 GAP-43與CaM結(jié)合,參與G蛋白相互作用,神經(jīng)遞質(zhì)的釋放,作用于胞吞/胞吐過程,通過小囊溶合或誘導(dǎo)生長錐和突觸前末端的胞吞促進(jìn)膜擴(kuò)展,與海馬長時(shí)程增強(qiáng)密切相關(guān). 神經(jīng)細(xì)胞黏附因子是細(xì)胞表面糖蛋白大家族的成員之一,促進(jìn)軸突生長,對長時(shí)記憶的保持有重要影響,同時(shí),GAP-43對其具調(diào)節(jié)作用，廣泛而深入地研究GAP-43意義深遠(yuǎn)。 |
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