国产精品一区二区三区高清不卡_中国一级特黄特色**毛片_大地资源在线观看官网第五页_yw1139龙物牢记永不失联_由国产一成人精品福利网站最新发布版本_日韩首页高清无码专区免费_影音先锋av资源男人站_黄色片操骚逼视频_欧美双性恋变态另类_日韩无码国产专区精品

最近搜索:細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>信號轉(zhuǎn)導與轉(zhuǎn)錄激活因子1抗體
信號轉(zhuǎn)導與轉(zhuǎn)錄激活因子1抗體
  • 產(chǎn)品貨號:
    BN41969R
  • 中文名稱:
    信號轉(zhuǎn)導與轉(zhuǎn)錄激活因子1抗體
  • 英文名稱:
    Rabbit anti-STAT1 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41969R-50ul

    50ul

    ¥1486.00

    交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41969R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41969R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱STAT1
中文名稱信號轉(zhuǎn)導與轉(zhuǎn)錄激活因子1抗體
別    名signal transducers and activators of transcription 1; DKFZp686B04100; ISGF 3; ISGF-3; Signal transducer and activator of transcription 1 91kDa; Signal transducer and activator of transcription 1 alpha/beta; STAT 1; STAT-1; STAT 91; STAT91; Transcription factor ISGF 3 components p91 p84; ; Transcription factor ISGF-3 components p91/p84; OTTHUMP00000163552; OTTHUMP00000165046; OTTHUMP00000165047; OTTHUMP00000205845; Signal transducer and activator of transcription 1, 91kD; Signal transducer and activator of transcription 1-alpha/beta; Signal Transductor and Activator of Transcription 1; STAT1_HUMAN; CANDF7; IMD31A; IMD31B; IMD31C.  
研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量84kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human STAT1:251-350/750 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-? and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3? is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Function:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Subunit:
Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C', C, Y1 and Y2 proteins, Nipah virus P, V and W proteins, and rabies virus phosphoprotein preventing activation of ISRE and GAS promoter. Interacts with HCV core protein; the interaction results in STAT1 degradation. Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its target gene. Interacts with SRC. Interacts with ERBB4 (phosphorylated). Interacts with PTK2/FAK1.

Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to IFN-gamma-induced tyrosine phosphorylation and dimerization.

Post-translational modifications:
Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. PHosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PKCdelta induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase.
Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.
ISGylated.

DISEASE:
Defects in STAT1 are the cause of STAT1 deficiency complete (STAT1D) [MIM:613796]. STAT1D is a disorder characterized by susceptibility to severe mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral illness.
Defects in STAT1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Defects in STAT1 are the cause of familial candidiasis type 7 (CANDF7) [MIM:614162]. A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Note=STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643).

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

SWISS:
P42224

Gene ID:
6772

Database links:

Entrez Gene: 6772 Human

Entrez Gene: 20846 Mouse

Entrez Gene: 25124 Rat

Omim: 600555 Human

SwissProt: P42224 Human

SwissProt: P42225 Mouse

Unigene: 642990 Human

Unigene: 743244 Human

Unigene: 277406 Mouse

Unigene: 33229 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.









































image.png

image.png

image.png

image.png

image.png

image.png

欧美日韩不卡高清在线看 | 亚洲第一综合天堂另类专 | 欧美AAAAAA级午夜福利视 | 国产精品久久免费视频 | 内射后入蘑菇视频ONLYYOU | 熟妇丰满videosxxxxx | 国产又色又爽又黄刺激蜜臀AV | 国产精品一区在线麻豆 | 国产素人在线观看人成视频 | 国产69精品久久久久APP下载 | 黄色视频在线免费观看 | 久久久精品日韩免费观看 | 99狠狠噜夜夜澡人人爽人人爽 | 人妻少妇精品视频一区二区三区 | 粗大的内捧猛烈进出在线视频 | 国产一级片内射毛片中出91 | 极品尤物喷水爆白浆呻吟小说 | 亚洲区中文字幕在线不卡电影 | 国产日韩欧美三级 | 国产精品青青在线麻豆 | 国产精品乱码久久久久久小说 | 亚洲精品自产拍在线观看 | 亚洲无人区码一二三码区别图片 | 插我舔内射18免费视频 | 法国新片《爱恋》尺度很大 | 日韩中文字幕在线看视频免费 | 男生女生在床上插插插的免费动漫 | 欧美日韩一区二区三区四区 | 宅男午夜大片又黄又爽大片 | 国产91av在线播放网站 | 国产精品宾馆精品酒店 | 久久亚洲AⅤ精品网站 | 一级做a爰片久久毛片潮喷妓女免费 | 黑人玩弄极品人妻系列 | 男人天堂·手机版在线 | 天美传媒TMY0013在线观看 | 又黄又湿免费高清视频 | 波多野结衣AV全免费观 | 羞羞汗汗YY歪歪漫画AV漫画 | 羞羞视频在线免费观看 | 涩涩视频在线播放 |