国产精品一区二区三区高清不卡_中国一级特黄特色**毛片_大地资源在线观看官网第五页_yw1139龙物牢记永不失联_由国产一成人精品福利网站最新发布版本_日韩首页高清无码专区免费_影音先锋av资源男人站_黄色片操骚逼视频_欧美双性恋变态另类_日韩无码国产专区精品

最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>腎母細(xì)胞瘤蛋白抗體
腎母細(xì)胞瘤蛋白抗體
  • 產(chǎn)品貨號:
    BN41959R
  • 中文名稱:
    腎母細(xì)胞瘤蛋白抗體
  • 英文名稱:
    Rabbit anti-Wilms Tumor Protein Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41959R-50ul

    50ul

    ¥1486.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Sheep,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41959R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Sheep,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41959R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Sheep,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Wilms Tumor Protein
中文名稱腎母細(xì)胞瘤蛋白抗體
別    名WIT 2; WT 1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms Tumor; Wilms tumor protein; Wilms' tumor gene; Wilms' tumor protein; WIT2; WT; WT1; WT-1; WT1_HUMAN; WT33.  



研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  腫瘤細(xì)胞生物標(biāo)志物  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Wilms Tumor Protein:301-400/449 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Function:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Subunit:
Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2. Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with FAM123B/WTX. Interacts with RBM4.

Subcellular Location:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
Isoform 1: Nucleus speckle.
Isoform 4: Nucleus, nucleoplasm.

Tissue Specificity:
Expressed in the kidney and a subset of hematopoietic cells.

DISEASE:
Defects in WT1 are the cause of Frasier syndrome (FS) [MIM:136680]. FS is characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant.
Defects in WT1 are the cause of Wilms tumor 1 (WT1) [MIM:194070]. WT is an embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms.
Defects in WT1 are the cause of Denys-Drash syndrome (DDS) [MIM:194080]. DDS is a typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic.

Similarity:
Belongs to the EGR C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.

SWISS:
P19544

Gene ID:
7490

Database links:

Entrez Gene: 7490 Human

Entrez Gene: 22431 Mouse

Entrez Gene: 24883 Rat

Omim: 607102 Human

SwissProt: P19544 Human

SwissProt: P22561 Mouse

SwissProt: P49952 Rat

Unigene: 591980 Human

Unigene: 389339 Mouse

Unigene: 92531 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


国产高清中文手机在线观看 | 国产超碰人人做人人爱ⅴA 一本久久a久久精品亚洲 | 晚上睡不着偷偷看B站 | 国产精品久久久久久久9999 | 亚欧洲精品在线视频免费观看 | 国产91精品太粉嫩高中在线观看 | 日本特级婬片a片免费手机版 | 女生扒开私处让男生插的 | 日韩欧美一区二区三区在线视频 | 亚洲 校园 欧美 国产 另类 | 亚洲熟妇一区二区三区 | 无码国产亚洲日韩国精品视频一区二区三区 | 国产精品一区二区尿失禁 | 亚洲精品午夜久久久久久久久 | 久久丁香婷深爱五月天网 | 黄乱色伦短篇小说 | 国产亚洲成AⅤ人片在线观看 | 亚洲综合网国产精品一区 | 插我一区二区在线观看 | 在线视频这里只有精品 | 成年免费视频播放网站推荐 | 久久99蜜桃精品久久久久小说 | 亚洲日韩在线观看 | 欧美日韩一区精品视频一区二区 | 蜜臀色欲AV在线播放国产日韩 | 乱码一二三乱码又大又粗 | 深夜爽爽动态图无遮无挡 | 内射一面膜上边一面膜下边 | 亚洲色欲AV无码成人专区 | 久久中文字幕亚洲一区二区 | 精品无人乱码一区二区三区 | 国产一级特黄在线播放 | 国产91色在线综合亚洲 | 国产乱女乱子视频在线播放 | 国产狂喷水潮免费网站www | 免费va国产高清大片在线 | 在线亚洲午夜片AV大片 | 一个人看的免费视频大全在线观看 | avtt天堂网手机版亚洲 | 久久国产乱子精品免费女 | 热热久久超碰精品中文字幕 |